ERICCA supports or leads a number of clinical trials.

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A randomised controlled trial of mindfulness-based cognitive therapy for psychosis

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This single-blind trial, led by Annie Yip and Professor Wai Tong Chien in Hong Kong, will recruit 95 participants with psychosis to either group Mindfulness-based CBT or group Psychoeducation. The primary outcome is emotional distress, and secondary outcomes include quality of life, symptoms and emotional regulation ability. Professor Thanos Karatzias and Dr Paul Hutton are collaborators and supervisors.

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A randomised controlled trial of group emotion regulation training for psychosis

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This randomised controlled trial, led by Amanda Woodrow and supervised by Paul Hutton, Thanos Karatzias and Sean Harper, will use 'ecological interventionist-causal' methodology to examine whether a therapeutic approach designed to improve emotion regulation will reduce paranoia in people with psychosis, compared to a control intervention. This novel experimental approach to understanding the causes of psychosis will employ 'real-time' experience sampling to examine the effects of the intervention and the relationship between emotion regulation improvements and paranoia.

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A randomised controlled trial of trauma-focused treatment for adult female prisoners

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This single-blind randomised controlled trial, led by Adam Mahoney and supervised by Thanos Karatzias, will determine whether trauma-focused therapy is effective for adult female prisoners who have experienced trauma. Recruitment for this trial is complete, and the results are currently being analysed.

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A controlled trial of applying a psychological model of care to an acute inpatient psychiatric environment.

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This open non-randomised controlled trial, led by Charlotte Paterson and supervised by Sean Harper, Thanos Karatzias, Nadine Dougall and Paul Hutton, will determine whether delivery of group psychological therapy in an acute psychiatric inpatient environment is feasible and acceptable, and associated with improvements in psychological distress, readmission rates and functioning. Recruitment for this trial is complete, and the results are currently being prepared for publication.

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Transdiagnostic emotion regulation group therapy for acute psychiatric inpatients: A pilot study

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This is an uncontrolled evaluation of a six session emotion regulation skills group for patients receiving acute inpatient mental healthcare, led by Dr Ruth Lennon and supervised by Sean Harper. The group was an open, rolling group piloted over a 5 month period, with two sessions delivered per week. Eight participants completed pre and post group ratings of emotion regulation, acceptance and distress. Results suggested the intervention is feasible and acceptable, with preliminary evidence identifying potential clinical benefits. Recruitment for this trial is complete, and the results (available here) are currently being prepared for publication.

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The effect of reducing the ‘jumping to conclusions’ bias on treatment decision-making capacity in psychosis: a randomised controlled trial with mediation analysis

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This open randomised controlled trial, led by Dr David Turner and supervised by Paul Hutton, will determine whether an intervention which reduces only the jumping to conclusions bias leads to improvements in treatment decision-making capacity in psychosis, when compared to an active 'attention control' condition. Recruitment for the trial is complete, and the results are currently being prepared for publication.

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Focusing on Clozapine Unresponsive Symptoms (FOCUS) trial: a randomised controlled trial

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This large single-blind multisite trial, led by Professor Tony Morrison and supported by over 30 colleagues throughout the UK, including Paul Hutton, will determine whether CBT is more effective than usual care for people with clozapine-resistant psychosis. Recruitment for the trial is complete, and the results are currently being prepared for publication.

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Cognitive Analytic Therapy for psychosis: A case series

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This proof-of-concept case series, led by Dr Peter Taylor and supported by Paul Hutton and others, will determine the acceptability and feasibility of providing and evaluating Cognitive Analytic Therapy (CAT) for psychosis. Recruitment is now complete and the results are currently under review for publication.

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Collaborative psychological assessment and formulation of impaired treatment decision-making capacity in psychosis: A case series

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This proof-of-concept case series, led by Dr Philip Murphy and supervised by Paul Hutton and others, will determine the acceptability and feasibility of a collaborative psychological approach to assessing and formulating the reasons for impaired treatment decision-making capacity in people with psychosis. Recruitment is now complete and the results are currently being prepared for publication.

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