Completed clinical trials led or supported by ERICCA
ERICCA members have led or supported a number of clinical trials, the results of which have now been published.
An international multi-site, randomised controlled trial of a mindfulness-based psycho- education group program for people with schizophrenia
This single-blind, multi-site, pragmatic randomised controlled trial, led by Professor Chien in Hong Kong and supported by Professor Karatzias and colleagues, was conducted in six community treatment facilities across three countries (Hong Kong, mainland China and Taiwan). 300 participants diagnosed with schizophrenia were allocated to mindfulness-based psychoeducation or usual care. The results are published in Psychological Medicine.
A randomised controlled trial of a mindfulness-based intervention program for people with schizophrenia: 6-month follow-up
This single-blind, multisite randomised controlled trial, led by Professor Chien in Hong Kong and supported by Professor Karatzias and colleagues, tested the effects of a mindfulness-based psychoeducation group program (MPGP in addition to usual care) versus a conventional psychoeducation group program (CPGP) versus treatment-as-usual (TAU) alone, with 138 people with schizophrenia spectrum disorders over a 6-month follow-up. The results are published in Neuropsychiatric Disease and Treatment.
Effectiveness and Acceptability of Group Psychoeducation for the Management of Mental Health Problems in Survivors of Child Sexual Abuse (CSA).
This was an uncontrolled study of the acceptability and effectiveness of brief group psychoeducation for 37 adult survivors of child sexual abuse. The results of this trial, led by Thanos Karatzias and colleagues, are published in the International Journal of Group Psychotherapy.
A controlled comparison of the effectiveness and efficiency of two psychological therapies for posttraumatic stress disorder.
This single-blind randomised controlled trial, led by Thanos Karatzias and colleagues, allocated 46 participants with PTSD to either EMDR or 'emotion freedom techniques'. The results are published in Journal of Nervous and Mental Disease.
A controlled comparison of eye movement desensitization and reprocessing versus exposure plus cognitive restructuring versus waiting list in the treatment of post-traumatic stress disorder.
In this single-blind trial, a total of 105 patients with PTSD were randomly allocated to EMDR versus exposure plus cognitive restructuring versus waiting list in a primary care setting. The results of this trial, led by Professor Kevin Power and supported by Thanos Karatzias and colleagues, are published in Clinical Psychology and Psychotherapy.
The ACTION trial (Assessment of Cognitive Therapy Instead of Neuroleptics)
This single-blind multisite trial, led by Professor Tony Morrison and supported by Paul Hutton and other colleagues, examined whether CBT was more effective than usual care for 74 people with psychosis who were not taking antipsychotic medication. The results are published in The Lancet.
This uncontrolled trial, led by Professor Tony Morrison and supported by Paul Hutton and other colleagues, examined whether CBT was acceptable and associated with clinical improvement in people with psychosis who were not taking antipsychotic medication. The results are published in Psychological Medicine.
Metacognitive Therapy for Treatment-Resistant Psychosis: A multiple-baseline study
This proof-of-concept case series led by Paul Hutton sought to determine the acceptability and feasibility of providing and evaluating Metacognitive Therapy (MCT) for psychosis. The results are published in Behavioural and Cognitive Psychotherapy
This pilot randomised controlled trial, led by Professor Tony Morrison and supported by Paul Hutton and other colleagues, sought to determine whether stigma-focused CBT was acceptable and feasible to deliver for people with psychosis with high internalised stigma. The results are published in Psychiatry Research.